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Our publications

33 peer-reviewed papers published by our own laboratory and its research partners between 2011 and 2026.

Mostly cell and tissue work: these papers establish mechanism, which is where a claim starts, not where it ends. Every entry links straight to PubMed and to the publisher.

Newest first. Search matches title, authors, journal, year and research area.

  1. In vitroOmega-3 fatty acids

    Omega-3-Based Nutraceuticals Suppress LPS-Induced Inflammatory Responses in Primary Human Monocytes

    Rose T, Schnierle P, Prinzen L, Fiebich BL

    Pharmaceuticals (Basel). 2026 Jul 1;19(7):1031.

    PMID 42515714DOI 10.3390/ph19071031

  2. In vitroPassiflora incarnata

    A Passiflora incarnata extract exerts multi-target effects on selected sleep-related receptors

    Appel K, Schwarzensteiner I, Zimmermann C, Tober C, Günnewich N

    J Ethnopharmacol. 2026 Jul 16;372:122198.

    PMID 42462921DOI 10.1016/j.jep.2026.122198

  3. In vitroCytoplasmic pollen extract (PureCyTonin®)

    The in vitro effects of purified and specific cytoplasmic pollen extract on dopaminergic and GABAergic systems

    Appel K, Chedraui P, Nappi RE, Palacios S, Genazzani AR, Simoncini T

    Gynecol Endocrinol. 2025 Dec 31;41(1):2566993.

    PMID 41085006DOI 10.1080/09513590.2025.2566993

  4. In vitroCimicifuga racemosa extract Ze 450

    Cimicifuga racemosa extract Ze 450 shifts macrophage immunometabolism and attenuates pro-inflammatory signaling

    Günther M, Paczia N, Michels S, Fiebich BL, Vogt S, Drewe J, Boonen G, Butterweck V, Culmsee C

    Biomed Pharmacother. 2025 Jul;188:118130.

    PMID 40382826DOI 10.1016/j.biopha.2025.118130

  5. In vitroLarch turpentine, turpentine and eucalyptus oil

    In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment

    Appel K, Rose T, Zimmermann C, Günnewich N

    Planta Med. 2024 Oct;90(13):1023-1029.

    PMID 39260387DOI 10.1055/a-2388-7527

  6. In vitroCimicifuga racemosa extract Ze 450

    AMPK Activation by Cimicifuga racemosa Extract Ze 450 Is Associated with Metabolic Effects and Cellular Resilience against Age-Related Pathologies in Different Tissue Cell Types

    Günther M, Schnierle P, Rose T, Schlegel J, Boonen G, Drewe J, Muñoz E, Fiebich BL, Culmsee C

    Pharmaceutics. 2024 Mar 13;16(3):393.

    PMID 38543287DOI 10.3390/pharmaceutics16030393

  7. In vitro and in vivoCannabidiol (CBD)

    Cannabidiol markedly alleviates skin and liver fibrosis

    Del Río C, Ruiz-Pino F, Prados ME, Fiebich BL, Tena-Sempere M, Muñoz E

    Front Pharmacol. 2022;13:981817.

    PMID 36339540DOI 10.3389/fphar.2022.981817

  8. Bibliometric analysisNatural product science network (INPST)

    The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

    Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR et al.

    Show all 161 authorsHide author list

    Singla RK, De R, Efferth T, Mezzetti B, Sahab Uddin M, Sanusi, Ntie-Kang F, Wang D, Schultz F, Kharat KR, Devkota HP, Battino M, Sur D, Lordan R, Patnaik SS, Tsagkaris C, Sai CS, Tripathi SK, Găman MA, Ahmed MEO, González-Burgos E, Babiaka SB, Paswan SK, Odimegwu JI, Akram F, Simal-Gandara J, Urquiza MS, Tikhonov A, Mondal H, Singla S, Lonardo SD, Mulholland EJ, Cenanovic M, Maigoro AY, Giampieri F, Lee S, Tzvetkov NT, Louka AM, Verma P, Chopra H, Olea SP, Khan J, Alvarez Suarez JM, Zheng X, Tomczyk M, Sabnani MK, Medina CDV, Khalid GM, Boyina HK, Georgiev MI, Supuran CT, Sobarzo-Sánchez E, Fan TP, Pittala V, Sureda A, Braidy N, Russo GL, Vacca RA, Banach M, Lizard G, Zarrouk A, Hammami S, Orhan IE, Aggarwal BB, Perry G, Miller MJ, Heinrich M, Bishayee A, Kijjoa A, Arkells N, Bredt D, Wink M, Fiebich BL, Kiran G, Yeung AWK, Gupta GK, Santini A, Lucarini M, Durazzo A, El-Demerdash A, Dinkova-Kostova AT, Cifuentes A, Souto EB, Zubair MAM, Badhe P, Echeverría J, Horbańczuk JO, Horbanczuk OK, Sheridan H, Sheshe SM, Witkowska AM, Abu-Reidah IM, Riaz M, Ullah H, Oladipupo AR, Lopez V, Sethiya NK, Shrestha BG, Ravanan P, Gupta SC, Alzahrani QE, Dama Sreedhar P, Xiao J, Moosavi MA, Subramani PA, Singh AK, Chettupalli AK, Patra JK, Singh G, Karpiński TM, Al-Rimawi F, Abiri R, Ahmed AF, Barreca D, Vats S, Amrani S, Fimognari C, Mocan A, Hritcu L, Semwal P, Shiblur Rahaman M, Emerald M, Akinrinde AS, Singh A, Joshi A, Joshi T, Khan SY, Balla GOA, Lu A, Pai SR, Ghzaiel I, Acar N, Es-Safi NE, Zengin G, Kureshi AA, Sharma AK, Baral B, Rani N, Jeandet P, Gulati M, Kapoor B, Mohanta YK, Emam-Djomeh Z, Onuku R, Depew JR, Atrooz OM, Goh BH, Andrade JC, Konwar B, Shine VJ, Ferreira JMLD, Ahmad J, Chaturvedi VK, Skalicka-Woźniak K, Sharma R, Gautam RK, Granica S, Parisi S, Kumar R, Atanasov AG, Shen B

    Phytomedicine. 2023 Jan;108:154520.

    PMID 36334386DOI 10.1016/j.phymed.2022.154520

  9. In vitro and in vivoMicro-immunotherapy (MIM-seq)

    A Micro-Immunotherapy Sequential Medicine MIM-seq Displays Immunomodulatory Effects on Human Macrophages and Anti-Tumor Properties towards In Vitro 2D and 3D Models of Colon Carcinoma and in an In Vivo Subcutaneous Xenograft Colon Carcinoma Model

    Jacques C, Marchesi I, Fiorentino FP, Chatelais M, Lilli NL, Appel K, Lejeune B, Floris I

    Int J Mol Sci. 2022 May 27;23(11):6059.

    PMID 35682738DOI 10.3390/ijms23116059

  10. Randomised clinical trialProbiotics (L. paracasei LPc-G110, L. plantarum GOS42)

    The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical Trial

    Volgenant CMC, van der Waal SV, Brandt BW, Buijs MJ, van der Veen MH, Rosema NAM, Fiebich BL, Rose T, Schmitter T, Gajfulin M et al.

    Show all 12 authorsHide author list

    Volgenant CMC, van der Waal SV, Brandt BW, Buijs MJ, van der Veen MH, Rosema NAM, Fiebich BL, Rose T, Schmitter T, Gajfulin M, Crielaard W, Zaura E

    Front Oral Health. 2022;3:825017.

    PMID 35434705DOI 10.3389/froh.2022.825017

  11. In vitroCannabis sativa L. extract (high CBD, low THC)

    Immunosuppressive activity of non-psychoactive Cannabis sativa L. extract on the function of human T lymphocytes

    Devi S, Zimmermann-Klemd AM, Fiebich BL, Heinrich M, Gründemann C, Steinberger P, Kowarschik S, Huber R

    Int Immunopharmacol. 2022 Feb;103:108448.

    PMID 34998274DOI 10.1016/j.intimp.2021.108448

  12. In vitro and in vivoCannabidiol derivative ((+)-CBD-HPE)

    (+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice

    González-Mariscal I, Carmona-Hidalgo B, Winkler M, Unciti-Broceta JD, Escamilla A, Gómez-Cañas M, Fernández-Ruiz J, Fiebich BL, Romero-Zerbo SY, Bermúdez-Silva FJ et al.

    Show all 12 authorsHide author list

    González-Mariscal I, Carmona-Hidalgo B, Winkler M, Unciti-Broceta JD, Escamilla A, Gómez-Cañas M, Fernández-Ruiz J, Fiebich BL, Romero-Zerbo SY, Bermúdez-Silva FJ, Collado JA, Muñoz E

    Pharmacol Res. 2021 Jul;169:105492.

    PMID 34019978DOI 10.1016/j.phrs.2021.105492

  13. In vitroUltra-low-dose cytokines (TNF-α, IL-1β)

    Pro-Inflammatory Cytokines at Ultra-Low Dose Exert Anti-Inflammatory Effect In Vitro: A Possible Mode of Action Involving Sub-Micron Particles?

    Floris I, Rose T, Rojas JAC, Appel K, Roesch C, Lejeune B

    Dose Response. 2020;18(4):1559325820961723.

    PMID 33633511DOI 10.1177/1559325820961723

  14. In vitroMagen-Darm-Entoxin®

    Magen-Darm-Entoxin® Shows Anti-Inflammatory Effects in vitro

    Günnewich N, Rose T, Koll K, Appel K

    Complement Med Res. 2021;28(5):473-477.

    PMID 33621979DOI 10.1159/000514525

  15. In vivo (animal model)Micro-immunotherapy (2LARTH®)

    The Micro-Immunotherapy Medicine 2LARTH® Reduces Inflammation and Symptoms of Rheumatoid Arthritis In Vivo

    Floris I, García-González V, Palomares B, Appel K, Lejeune B

    Int J Rheumatol. 2020;2020:1594573.

    PMID 32180808DOI 10.1155/2020/1594573

  16. In vitroSemi-synthetic cannabinoid derivatives

    Structure-Effect Relationships of Novel Semi-Synthetic Cannabinoid Derivatives

    Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C et al.

    Show all 12 authorsHide author list

    Götz MR, Collado JA, Fernández-Ruiz J, Fiebich BL, García-Toscano L, Gómez-Cañas M, Koch O, Leha A, Muñoz E, Navarrete C, Pazos MR, Holzgrabe U

    Front Pharmacol. 2019;10:1284.

    PMID 31824305DOI 10.3389/fphar.2019.01284

  17. In vitroMicro-immunotherapy (2LARTH®)

    2LARTH®, a micro-immunotherapy medicine, exerts anti-inflammatory effects in vitro and reduces TNF-α and IL-1β secretion

    Floris I, Appel K, Rose T, Lejeune B

    J Inflamm Res. 2018;11:397-405.

    PMID 30464572DOI 10.2147/JIR.S174326

  18. Ex vivoProbiotic strains for periodontal health

    Ex vivo anti-inflammatory effects of probiotics for periodontal health

    Schmitter T, Fiebich BL, Fischer JT, Gajfulin M, Larsson N, Rose T, Goetz MR

    J Oral Microbiol. 2018;10(1):1502027.

    PMID 30057719DOI 10.1080/20002297.2018.1502027

  19. Project overviewMediterranean food plants (MediHealth)

    Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources-The MediHealth Project

    Waltenberger B, Halabalaki M, Schwaiger S, Adamopoulos N, Allouche N, Fiebich BL, Hermans N, Jansen-Dürr P, Kesternich V, Pieters L et al.

    Show all 19 authorsHide author list

    Waltenberger B, Halabalaki M, Schwaiger S, Adamopoulos N, Allouche N, Fiebich BL, Hermans N, Jansen-Dürr P, Kesternich V, Pieters L, Schönbichler S, Skaltsounis AL, Tran H, Trougakos IP, Viljoen A, Wolfender JL, Wolfrum C, Xynos N, Stuppner H

    Molecules. 2018 May 6;23(5):1097.

    PMID 29734769DOI 10.3390/molecules23051097

  20. In vitro and in vivoCannabidiol quinone derivative (VCE-004.8)

    Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy

    Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jiménez-Jiménez C, Mestre L, Feliú A, Bellido ML, Fiebich BL, Appendino G et al.

    Show all 13 authorsHide author list

    Navarrete C, Carrillo-Salinas F, Palomares B, Mecha M, Jiménez-Jiménez C, Mestre L, Feliú A, Bellido ML, Fiebich BL, Appendino G, Calzado MA, Guaza C, Muñoz E

    J Neuroinflammation. 2018 Mar 1;15(1):64.

    PMID 29495967DOI 10.1186/s12974-018-1103-y

  21. In vitroImmulina® and immunLoges® (Spirulina extract)

    Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses

    Appel K, Munoz E, Navarrete C, Cruz-Teno C, Biller A, Thiemann E

    Plants (Basel). 2018 Feb 26;7(1):13.

    PMID 29495393DOI 10.3390/plants7010013

  22. In vivo (animal model)Clinoptilolite (zeolite)

    Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation

    Nizet S, Muñoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D et al.

    Show all 14 authorsHide author list

    Nizet S, Muñoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D, Scheichl L, Meisslitzer-Ruppitsch C, Freissmuth M, Berger T

    Inflamm Bowel Dis. 2017 Dec 19;24(1):54-66.

    PMID 29272495DOI 10.1093/ibd/izx042

  23. In vitroThymoquinone

    Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling

    Velagapudi R, Kumar A, Bhatia HS, El-Bakoush A, Lepiarz I, Fiebich BL, Olajide OA

    Int Immunopharmacol. 2017 Jul;48:17-29.

    PMID 28458100DOI 10.1016/j.intimp.2017.04.018

  24. In vitroCapsaicin

    Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s

    Bhatia HS, Roelofs N, Muñoz E, Fiebich BL

    Sci Rep. 2017 Mar 8;7(1):116.

    PMID 28273917DOI 10.1038/s41598-017-00225-5

  25. In vitroArtemether

    Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms

    Okorji UP, Velagapudi R, El-Bakoush A, Fiebich BL, Olajide OA

    Mol Neurobiol. 2016 Nov;53(9):6426-6443.

    PMID 26607631DOI 10.1007/s12035-015-9543-1

  26. In vitroRice bran derivatives

    Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway

    Bhatia HS, Baron J, Hagl S, Eckert GP, Fiebich BL

    J Neuroinflammation. 2016 Jun 14;13(1):148.

    PMID 27301644DOI 10.1186/s12974-016-0615-6

  27. In vitroPoly(I:C) / mPGES-1 and COX-2

    Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

    de Oliveira AC, Yousif NM, Bhatia HS, Hermanek J, Huell M, Fiebich BL

    J Neuroinflammation. 2016 Jan 18;13:11.

    PMID 26780827DOI 10.1186/s12974-015-0473-7

  28. In vitromicroRNA-26a

    microRNA-26a modulates inflammatory response induced by toll-like receptor 4 stimulation in microglia

    Kumar A, Bhatia HS, de Oliveira AC, Fiebich BL

    J Neurochem. 2015 Dec;135(6):1189-202.

    PMID 26376347DOI 10.1111/jnc.13364

  29. In vitroChokeberry (Aronia melanocarpa) and selenium

    Chokeberry (Aronia melanocarpa (Michx.) Elliot) concentrate inhibits NF-κB and synergizes with selenium to inhibit the release of pro-inflammatory mediators in macrophages

    Appel K, Meiser P, Millán E, Collado JA, Rose T, Gras CC, Carle R, Muñoz E

    Fitoterapia. 2015 Sep;105:73-82.

    PMID 26079445DOI 10.1016/j.fitote.2015.06.009

  30. In vitro5-HT3 receptor antagonists

    Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes

    Stratz C, Anakwue J, Bhatia H, Pitz S, Fiebich BL

    Int Immunopharmacol. 2014 Sep;22(1):160-6.

    PMID 24975660DOI 10.1016/j.intimp.2014.06.003

  31. In vitroPicralima nitida seed extract

    Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL-1β-stimulated SK-N-SH neuronal cells

    Olajide OA, Velagapudi R, Okorji UP, Sarker SD, Fiebich BL

    J Ethnopharmacol. 2014 Mar 14;152(2):377-83.

    PMID 24491645DOI 10.1016/j.jep.2014.01.027

  32. In vitroHDAC inhibitors (valproic acid, sodium butyrate)

    Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia

    Singh V, Bhatia HS, Kumar A, de Oliveira AC, Fiebich BL

    Neuroscience. 2014 Apr 18;265:147-57.

    PMID 24480366DOI 10.1016/j.neuroscience.2014.01.037

  33. In vitroPassiflora incarnata

    Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L

    Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G

    Phytother Res. 2011 Jun;25(6):838-43.

    PMID 21089181DOI 10.1002/ptr.3352

How to read this list. Most of these are in-vitro or ex-vivo studies. They show that a compound acts on a pathway in a defined cell system — not that it benefits a person. On our own Claim Readiness scale that is Emerging evidence, and it carries no health claim on its own. The clinical literature we appraise for briefs is cited on the ingredient and health indication pages; how we tell the two apart is set out in the methodology.

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